Table 1: Currently Available NSAIDs in the United States for Mild to Moderate Nociceptive Pain Chemical Class Propionic Acids
COX-2 Inhibitor
Naproxen sodium
Naproxen sodium Celecoxib
Generic Name Fenoprofen Flurbiprofen Ibuprofen Ibuprofen Ketoprofen Naproxen
Brand name(s) Prescription status Oral dosage formulations and usual adult dosages
Nalfon
Ansaid Advil, Motrin Caldalor
Relafen
Naprosyn
Aleve
Anaprox
Celebrex
Rx
Rx
OTC and Rx
Rx
Rx
Rx
OTC
Rx
Rx
400mg once then 200 mg q12h
200 mg q4-6h
Tablets: 200-400 mg q4-6h
250 mg q6- 8h or 500 mg q12h
275 mg q6- 8h or 550 mg q12h
100 mg q12h
IV: 400-800 mg q6h
50 mg q6h or 75 mg q8h
220 mg q8- 12h
2,400 (1,200mg
300 (extended- release
Maximum recommended daily dose (mg)
for OTC and 3,200mg for osteoarthritis & rheumatoid arthritis)
1,250 first day, then 1,000
1,375 first day, then 1,100
600 first day, then 400
format is a 200mg
3,200
300
3,200
660
capsule with a max. dose of 200mg/d)
Less effective than full doses of naproxen or ibuprofen; does not interfere with platelet function.
Liquid: 25 mg/5 mL; 250 mg probably comparable to aspirin 650 mg with longer duration.
FDA- approved only for use in osteoarthritis & rheumatoid arthritis.
100 mg/mL IV solution; 200 mg equal to aspirin or acetamino- phen 650mg.
25 mg comparable to ibuprofen 400mg; 50mg
440 mg comparable to 400 mg ibuprofen with longer duration.
275 mg comparable to aspirin 650 mg with longer duration.
Liquid: 20- 40 mg/mL.
Notes
superior to acetamino- phen/ codeine.
Chemical Class
Nonacidic Agent
Salicylic Acid Derivative
Oxicam
Fenamates
Mefenamic acid
Generic Name Nabumetone
Diflunisal
Salsalate Meloxicam Piroxicam Meclofenamate
Acetaminophen**
Brand name(s) Prescription status Oral dosage formulations and usual adult dosages Maximum recommended daily dose (mg)
Relafen
Dolobid
Disalcid
Mobic
Feldene
Meclomen
Ponstel
Tylenol
Rx
Rx
Rx
Rx
Rx
Rx
Rx
OTC
500mg q6h or 1,000 mg q12h
500mg once then 250 mg q6h
500-750 mg q8-12h
500 mg q8- 12h
7.5-15 mg qd
10-20 mg q12-24h
650 mg q4-6h or 1,000 mg q6-8h
50-100 mg q4h
1,250 first day, then 1,000
2,000
1,500
3,000
15
20
400
4,000
500 mg comparable to aceta- minophen or aspirin 650mg with slower onset and longer duration.
FDA- approved only for osteoarthritis & rheumatoid arthritis.
FDA- approved only for
Amount in prescription combination products limited to 325 mg/dosage unit.
Does not interfere
Maximum therapy of 1 week.
Notes
osteoarthritis & rheumatoid arthritis.
with platelet aggregation.
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