___________________________________________________________________________ Colorectal Cancer
COMBINATION CHEMOTHERAPY REGIMENS USED IN THE TREATMENT OF COLON AND RECTAL CANCER Name Agents Regimen Arbeitsgemeinschaft Internistische Onkologie (AIO) or German AIO Folic acid (leucovorin), 5-FU, and irinotecan Irinotecan (100 mg/m 2 ) and leucovorin (500 mg/m 2 ) administered as two-hour infusions on day 1, followed by 5-FU (2,000 mg/m 2 ) IV bolus administered via ambulatory pump weekly over 24 hours, four times per year (52 weeks)
Capecitabine (1,000 mg/m 2 ) twice daily on days 1 through 14, plus oxaliplatin (70 mg/m 2 ) on days 1 and 8 every three weeks Irinotecan (180 mg/m 2 ) administered as a two-hour infusion on day 1, leucovorin (200 mg/m 2 ) administered as a two-hour infusion on days 1 and 2, followed by a loading dose of 5-FU (400 mg/m 2 ) IV bolus, then 5-FU (600 mg/m 2 ) administered via ambulatory pump over 22 hours every two weeks on days 1 and 2 Irinotecan (180 mg/m 2 ) and leucovorin (400 mg/m 2 ) administered as two- hour infusions on day 1, followed by a loading dose of 5-FU (400 mg/m 2 ) IV bolus administered on day 1, then 5-FU (2,400–3,000 mg/m 2 ) administered via ambulatory pump over 46 hours every two weeks Oxaliplatin (85–100 mg/m 2 ) and leucovorin (400 mg/m 2 ) administered as two-hour infusions on day 1, followed by a loading dose of 5-FU (400 mg/ m 2 ) IV bolus on day 1, then 5-FU (2,400–3,000 mg/m 2 ) administered via ambulatory pump over 46 hours every two weeks Oxaliplatin (130 mg/m 2 ) and leucovorin (400 mg/m 2 ) administered as two- hour infusions on day 1, followed by a loading dose of 5-FU (400 mg/m 2 ) IV bolus administered over 46 hours on day 1, then 5-FU (2,400 mg/m 2 ) administered via ambulatory pump over 46 hours beginning on day 1, every two weeks, for a total of eight cycles Irinotecan (165 mg/m 2 ) administered as a 60-minute infusion, then concomitant infusion of oxaliplatin (85 mg/m 2 ) and leucovorin (200 mg/ m 2 ) over 120 minutes, followed by 5-FU (3,200 mg/m 2 ) administered as a 48-hour continuous infusion.
CAPOX
Capecitabine and oxaliplatin Folic acid (leucovorin), 5-FU, and irinotecan
Douillard
FOLFIRI
Leucovorin, 5-FU, and irinotecan
FOLFOX6
Oxaliplatin, leucovorin, and 5-FU
FOLFOX7
Oxaliplatin, leucovorin, and 5-FU
FOLFOXIRI
Irinotecan, oxaliplatin, leucovorin, and 5-FU
5-FU and leucovorin Leucovorin (200 mg/m 2 ) administered as a 2-hour infusion on days 1 and 2, followed by a loading dose of 5-FU (600 mg/m 2 ) IV bolus over 22 hours on days 1 and 2 every two weeks
FU-LV (Roswell Regimen)
Irinotecan (125 mg/m 2 ) plus 5-FU (500 mg/m 2 ) IV bolus and leucovorin (20 mg/m 2 ) IV bolus administered weekly for four out of six weeks Oral capecitabine (1,000 mg/m 2 ) administered twice daily for 14 days plus oxaliplatin (130 mg/m 2 ) IV infusion administered over 2 hours on day 1 every 3 weeks
IFL (or Saltz)
Irinotecan, 5-FU, and leucovorin
XELOX
Oxaliplatin and capecitabine
Source: [221; 222, 272]
Table 11
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MDFL2626
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