___________________________________________________________________________ Colorectal Cancer
19. Which of the following statements concerning the use of COX-2 inhibitors and colorectal cancer is FALSE? A) The benign toxicity profile of COX-2 inhibitors supports their long-term use. B) There is a significant reduction in colorectal cancer among regular aspirin users. C) COX-2 inhibitors may reduce polyp numbers and size in patients with familial adenomatous polyposis (FAP). D) COX-2 inhibitors may increase disease-free and overall survival after resection of stage III colon cancer. 20. Which of the following statements regarding hormone replacement in postmenopausal women and colorectal cancer risk is TRUE? A) Conjugated equine estrogens improve the survival rate in invasive colorectal cancer. B) Women receiving active hormone therapy have a significantly lower risk of colorectal cancer.
24. In which of the following hereditary syndromes is colorectal cancer risk by 40 years of age near 100%? A) FAP
B) Lynch syndrome C) Attenuated FAP D) Peutz-Jeghers syndrome
25. Risk of extracolonic malignancy in patients with Lynch syndrome is greatest for A) prostate cancer.
B) endometrial cancer. C) small bowel cancer. D) urinary tract cancer.
26. In patients with inflammatory bowel disease, colorectal cancer risk and appropriate risk management are determined by
A) histologic findings. B) symptom severity. C) endoscopic findings. D) family history findings.
C) There are no harms associated with postmenopausal therapy with combined estrogen and progestin. D) Colorectal cancer that develops in women taking postmenopausal hormone therapy is less likely to be at an advanced stage when detected.
27. The United States is the only developed country with declining colorectal cancer rates, largely the result of
A) increasing screening. B) decreasing risk factors. C) advances in chemotherapy. D) None of the above
21. In initial patient assessment, which of the following is NOT considered a colorectal cancer “red flag” for further inquiry? A) History of 10 or more polyps B) Diagnosis of two or more Lynch-associated cancers C) Family history of colorectal cancer diagnosed before 50 years of age D) Personal history of endometrial cancer diagnosed at any age 22. What proportion of colorectal cancer cases are sporadic disease without apparent inherited origin?
28. The preferred colorectal cancer screening modality is A) optical colonoscopy. B) flexible sigmoidoscopy. C) stool DNA mutation tests. D) computed tomography (CT) colonography. 29. Which of the following statements regarding colonoscopy screening for colorectal cancer is TRUE? A) Most serious colonoscopy complications occur in younger patients. B) Up to 60% of colorectal malignancies may be missed by colonoscopy. C) Colonoscopy is the screening method with highest levels of patient acceptance and compliance. D) Colonoscopy is the method to verify positive results with all other colorectal cancer screening methods.
A) 25% B) 50% C) 75% D) 90%
23. Which of the following places a patient at high risk of colorectal cancer? A) Sessile adenomas B) Family history of Lynch syndrome C) More than 10 adenomas on a single examination D) Two second-degree relatives with colorectal cancer
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