1 Table of contents 289

Florida Psychology Ebook Continuing Education

Table 10: FDA Categorization of Psychotropic Medication Risk in Pregnancy & Lactation (Continued) Drug Category Drugs FDA Pregnancy Category* AAP Rating

Lactation Risk Category†

Tricyclics & Heterocyclics

Amitriptyline

C

Unknown, of concern

L2

Amoxapine (Asendin)‡

C

Unknown, of concern

L2

Clomipramine (Anafranil)

C

Unknown, of concern

L2

Desipramine (Norpramin)

C

Unknown, of concern

L2

Doxepin (Sinequan)‡

C

Unknown, of concern

L5

Imipramine (Tofranil)

C

Unknown, of concern

L2

Maprotiline (Ludiomil)‡

B

NA

L3

Nortriptyline (Pamelor)

C

Unknown, of concern

L2

Protriptyline (Vivactil)

C

NA

NA

Selective Serotonin Reuptake Inhibitors

Citalopram (Celexa)

C

NA

L3

Escitalopram (Lexapro)

C

NA

L3 in older infants

Fluoxetine (Prozac)

C

Unknown, of concern

L2 in older infants; L3 in neonates

Fluvoxamine (Luvox)‡

C

Unknown, of concern

L2

Paroxetine (Paxil)

D

Unknown, of concern

L2

Sertraline (Zoloft)

C

Unknown, of concern

L2

Other Antidepressants

Bupropion (Wellbutrin)

B

Unknown, of concern

L3

Duloxetine (Cymbalta)

C

NA

NA

Mirtazapine (Remeron)

C

NA

L3

Nefazodone (Serzone)‡

C

NA

L4

Trazodone (Desyrel)‡

C

Unknown, of concern

L2

Venlafaxine (Effexor)

C

NA

L3

Antipsychotics

Aripiprazole (Abilify)

C

NA

L3

Chlorpromazine (Thorazine)‡ C

Unknown, of concern

L3

Clozapine (Clozaril)

B

Unknown, of concern

L3

Fluphenazine (Prolixin)‡

C

NA

L3

Haloperidol (Haldol)

C

Unknown, of concern

L2

Loxapine (Loxitane)

C

NA

L4

Olanzapine (Zyprexa)

C

NA

L2

Perphenazine (Trilafon)‡

C

Unknown, of concern

NA

Pimozide (Orap)

C

NA

L4

Quetiapine (Seroquel)

C

Unknown, of concern

L4

Risperidone (Risperdal)

C

NA

L3

Thioridazine (Mellaril)‡

C

NA

L4

Trifluoperazine (Stelazine)‡ NA * FDA drug safety categories: A = controlled studies show no risk; B = no evidence of risk in humans; C = risk cannot be ruled out; D = positive evidence of risk; X = contraindicated in pregnancy. † Lactation risk categories: L1 = safest; L2 = safer; L3 = moderately safe; L4 = possibly hazardous; L5 = contraindicated. ‡ Brand name no longer available in the U.S. C Unknown, of concern

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