Table 2: Selective Serotonin Reuptake Inhibitors (SSRIs), Non-SSRIs, & Tricyclic Antidepressants (TCAs) Generic and Brand Names Initial Dosage Maximum Dosage Major Adverse Effects Selective Serotonin Reuptake Inhibitors (SSRIs) Citalopram (Celexa)
10 to 20 mg per day 10 to 40 mg per day Nausea, vomiting, dry mouth, headache, somnolence, insomnia, increased sweating, tremor, diarrhea, sexual dysfunction
Escitalopram (Lexapro)
10 mg per day
5 to 20 mg per day
Suicidal behavior, fever, insomnia, dizziness, somnolence, paresthesia, lightheadedness, migraine, tremor, vertigo, abnormal dreams, irritability, fatigue, lethargy, palpitations, hypertension, flushing, chest pain, nausea, diarrhea, constipation, indigestion, vomiting, dry mouth, heartburn, flatulence, gastroesophageal reflux, ejaculation disorder, urinary frequency Nausea, vomiting, diarrhea, insomnia, nervousness, restlessness, agitation, anxiety, lightheadedness, drowsiness, fatigue, headache, tremor, initial weight loss, possible long-term weight gain, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), increased risk of bleeding (upper gastrointestinal and intraoperative) with coadministration of nonsteroidal anti-inflammatory drugs, aspirin, and warfarin (Coumadin) Headache, somnolence, dizziness, insomnia, dry mouth, constipation, diarrhea, ejaculatory disturbances, weakness, diaphoresis
Fluoxetine (Prozac)
10 mg per day
5 to 40 mg per day
Paroxetine (Paxil, Paxil CR)
10 mg per day
5 to 40 mg per day
Sertraline (Zoloft)
12.5 to 25 mg per day
25 to 200 mg per day Insomnia, somnolence, dizziness, headache, fatigue, dry mouth, diarrhea, nausea, ejaculatory disturbances
Non-SSRIs Buproprion (Wellbutrin,
37.5 to 75 mg per day; SR: 75 to 100 mg every morning; XL: 150 mg every morning
150 mg in two to three divided dosages; SR: 100 mg twice per day; XL: 150 mg per day
Dizziness, anxiety, agitation, dry mouth, insomnia, headache, nausea, constipation or diarrhea, tremor
Wellbutrin SR, Wellbutrin XL)
Duloxetine (Cymbalta)
20 mg per day
20 to 60 mg per day Nausea, dry mouth, constipation, poor appetite, diarrhea, headache, insomnia, somnolence, fatigue, diaphoresis, dizziness
Mirtazapine (Remeron, Remeron SolTab) Venlafaxine (Effexor, Effexor XR)
7.5 mg at bedtime 7.5 to 45 mg at bedtime
Somnolence, increased appetite with weight gain, increased serum cholesterol, constipation, dry mouth Headache, somnolence, dizziness, insomnia, nervousness, nausea, dry mouth, constipation, anorexia, abnormal ejaculation/orgasm, weakness, diaphoresis Serotonin syndrome, anticoagulant effect with warfarin, cardiotoxicity, orthostasis, hypotension, hypertension, anticholinergic effects, tremor, agitation, insomnia Orthostasis, hypertension, myocardial infarction, ataxia, extrapyramidal symptoms, seizures, glucose dysregulation, SIADH, sexual dysfunction, dry mouth, anorexia, constipation, nausea, vomiting, diarrhea, weight gain/loss, urinary retention, impotence, blood dyscrasia, increased levels in liver function test values, paresthesia, mydriasis
25 mg twice per day; XR: 37.5 mg per day
150 mg per day in divided dosages; XR: 150 mg per day
Tricyclic Antidepressants (TCAs) Desipramine (Norpramin)
25 mg per day
100 mg per day
Nortriptyline (Pamelor)
10 to 25 mg per day 50 mg per day
EliteLearning.com/Psychology
Book Code: PYFL4024
Page 177
Powered by FlippingBook