Table 12. Buprenorphine-Containing Products FDA-Approved for Opioid Use Disorder Product Name Available Strengths
Route(s) of Administration
Buprenorphine 1 mg/naloxone 0.2 mg Buprenorphine 2.1 mg/naloxone 0.3 mg Buprenorphine 4.2 mg/naloxone 0.7 mg Buprenorphine 6.3 mg/naloxone 1 mg
Bunavail buccal films
Buccal
Probuphine implant
Buprenorphine 74.2 mg
Subdermal
Sublocade extended-release solution for injection
Buprenorphine 100mg/0.5 mL Buprenorphine 300 mg/1.5 mL
Subcutaneous
Buprenorphine 2 mg Buprenorphine 8 mg
Subutex sublingual tablets
Sublingual
Buprenorphine 2 mg/naloxone 0.5 mg Buprenorphine 8 mg/naloxone 2 mg Buprenorphine 2 mg/naloxone 0.5 mg Buprenorphine 4 mg/naloxone 1 mg Buprenorphine 8 mg/naloxone 2 mg Buprenorphine 12 mg/naloxone 3 mg Buprenorphine 0.7 mg/naloxone 0.18 mg Buprenorphine 1.4 mg/naloxone 0.36 mg Buprenorphine 2.9 mg/naloxone 0.71 mg Buprenorphine 5.7 mg/naloxone 1.4 mg Buprenorphine 8.6 mg/naloxone 2.1 mg Buprenorphine 11.4 mg/naloxone 2.9 mg
Suboxone sublingual tablets
Sublingual
Suboxone sublingual films
Sublingual, buccal
Zubsolv sublingual tablets
Sublingual
Naltrexone As mentioned previously, naltrexone is considered first-line therapy for individuals with moderate or severe alcohol use disorder but is also an option for treatment of OUD via its effects on the mu receptor. Efficacy of naltrexone has been mixed in some studies when compared to traditional treatment for opioid use in particular; its use should be customized to the individual. 130 Different in mechanism from methadone or buprenorphine, naltrexone is an opioid antagonist medication available in both PO and IM formulation. It can be prescribed by any licensed provider without the need for special requirements linked to buprenorphine or methadone. There is no abuse potential. It is currently approved for the treatment of both OUD and for the treatment of alcohol abuse. As opposed to methadone and buprenorphine, naltrexone is not a controlled substance, so it can be prescribed by any healthcare provider who is licensed to prescribe medications. However, as an opioid antagonist, use of naltrexone must be monitored closely to prevent serious acute withdrawal symptoms.
Book Code: TN24CME
Page 59
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